Experiment: A three-day 7T fMRI study of Fear Conditioning, Extinction, and Recall in healthy adults aged 20-35 years Public Published
This study examines fear conditioning and extinction-related learning processes in healthy adults aged 20-35 years using a three-day differential conditioning paradigm during 7 Tesla functional magnetic resonance imaging. Participants are presented with two visual geometric stimuli (CS+ and CS-), of which one stimulus is repeatedly paired with a mildly aversive electrical stimulation to the hand during acquisition training, while the second stimulus is never paired. On the following days, extinction, extinction recall, reacquisition, and reextinction phases are performed to assess neural and autonomic responses to learned threat, safety learning, and unexpected omission of the aversive stimulus. Concurrent recordings include BOLD fMRI, skin conductance and pupillometry. The study aims to identify the neural circuits underlying fear extinction learning, with particular emphasis on cerebellar and midbrain involvement during the unexpected omission of the unconditioned stimulus. Latest revised reviewed preprint on the eLife website: https://elifesciences.org/reviewed-preprints/105399
Subjects, sessions, modalities and files in experiment
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- 20-99664-BO
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- 2026-05-21
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- 20240415